Medsamic Dosage/Direction for Use

The recommended standard dose is 5 to 10 ml by slow intravenous injection at a rate of 1ml/minute two to three times daily.
For the indications listed below the following doses are recommended: General fibrinolysis: 1.0 g (2 ampoules of 5 ml) by slow intravenous injection every six to eight hours.
Prostatectomy: 1 to 2 ampoules of 5 ml by slow intravenous injection every six to eight hours (the first injection being given during the operation) for the first three days after surgery, thereafter an oral available form of tranexamic acid 1 to 1.5 g (2 to 3 tablets) two to three times daily until macroscopic haematuria is no longer present.
Epistaxis: Medsamic solution for injection may be applied topically to the nasal mucosa of patients suffering from epistaxis. This can be done by soaking a gauze strip in the solution, and then packing the nasal cavity.
Menorrhagia: Medsamic therapy is initiated when bleeding has become profuse.
Dental extraction in patients with coagulopathies: Immediately before surgery, Medsamic 10 mg per kg body-weight should be given intravenously. After surgery, 25 mg per kg bodyweight of an oral available form of tranexamic acid is given three to four times daily for six to eight days. Coagulation factor concentrate might be necessary to administrate. This decision should be taken after consulting specialists on coagulation.
For patients with moderate to severe impaired renal function, the following dosages are recommended: (See table.)

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