Medomycin (Doxycycline) is a true broad spectrum antibiotic, alpha-6-deoxy-5-oxytetracycline. Medomycin (Doxycycline) possesses properties not observed with previously available tetracyclines: its greater absorption from the gastrointestinal tract and its once-a-day dosage.
Medomycin (Doxycycline) displays activity against both gram-positive and gram-negative, organisms. While the spectrum of Medomycin is essentially that of the other tetracyclines, certain strains of S. aureus, have exhibited greater susceptibility in vitro to Medomycin, Clinical experience has shown that Medomycin (Doxycycline) differs from other tetracyclines by its remarkable absorption after oral administration and prolonged duration of antibacterial activity. Because of these, oral administration of only once-daily achieves therapeutic results highly comparable to those of other tetracyclines that require multiple daily doses. Bacteriological studies have shown that Medomycin (Doxycycline) disturbs the normal intestinal flora to a substantially lower degree than do standard doses of other tetracyclines. The absorption of Medomycin (Doxycycline) is not significantly influenced by the ingestion of food or milk, which impair the absorption of other tetracyclines. Thus Medomycin (Doxycycline) can be administered without regard to meals. Since the plasma half-life has been shown not to increase in patients with renal impairment. Medomycin (Doxycycline) is the tetracycline of choice in these patients.
Specific conditions which have responded successfully to Medomycin (Doxycycline) therapy include the following: Respiratory infections. Acute Bronchitis and acute exacerbations of chronic bronchitis, bronchiectasis, single and multiple pneumonia, lung abscess, and upper respiratory tract infections such as pharyngitis, and laryngotracheitis, E.N.T: Otitis media, sinusitis, tonsillitis, Genitourinary Tract infections (acute and chronic): Cystitis, prostatitis, pyelonephritis, trigonitis, urethritis (gonococcal) and other. Skin and soft Tissue Infections: Abscess, acne vulgaris and conglobata, furunculosis, impetigo, infected burns, cellulitis, infected eczema and other infected rashes or dermatoses, infected traumatic and postoperative wounds, omphalitis and paronychia. Digestive System Infections: Cholangitis, cholecystitis, peritonitis, Salmonellosis, Shigellosis, typhoid fever Obstetrical and Gynecological Infections; Acute puerperal infections and pelvic inflammatory disease. Other Infections: Lymphogranuloma venereum, osteomyelitis, thrombophlebitis.
The recommended oral dose of Medomycin (Doxycycline) in adults for the majority of susceptible is 200mg on the first day of treatment followed by a maintenance dose of 100mg per day. In the management of more severe infections (particularly chronic infections of the urinary tract) 200mg daily should be used throughout the treatment period. The daily dose may be administered once a day, or in two equally divided doses. Acute gonococcal anterior urethritis in males - a single dose of 300mg or 100mg b.i.d. for 2-4 days. Acute gonococcal infections in the adult female should be treated with doses of 100mg b.i.d until cure is effected. In the treatment of primary and secondary syphilis the recommended dosage is 200mg daily for at least 10 days. When used in streptococcal infections, therapy should be at least continued for 10 days to prevent the development of rheumatic fever of glomerulonephritis.
General: Therapy should be continued beyond the time that symptoms and fever have subsided, although antibacterial levels may usually be present up to 36 hours following discontinuation of Medomycin (Doxycycline). Absorption of Medomycin (Doxycycline), unlike other tetracyclines, is not significantly impaired by simultaneous ingestion of food or milk. As with other tetracyclines, aluminium hydroxide antacids have been shown to decrease absorption, and should be avoided.
This drug is contraindicated in individuals who have shown hypersensitivity to tetracyclines.
Not recommended for children less than 12 years old and not to be used in pregnant women.
Nausea, vomiting and occasionally diarrhoea, as well as reactions of an allergic nature may occur. If severe adverse reactions, individual idiosyncrasy, or allergy occur, discontinue medication.
J01AA02 - doxycycline ; Belongs to the class of tetracyclines. Used in the systemic treatment of infections.
Medomycin cap 100 mg
100 × 10's
Sign Out
