There is limited experience with overdose of MAVENCLAD. Lymphopenia is known to be dose-dependent (refer to Precautions and Adverse Reactions).
There is no known specific antidote to an overdose of MAVENCLAD. Treatment consists of careful observation and initiation of appropriate supportive measures. Discontinuation of MAVENCLAD may need to be considered. Because of the extensive intracellular and tissue distribution, haemodialysis is unlikely to eliminate cladribine to a significant extent.
Particularly close monitoring of haematological parameters is recommended in patients who have been exposed to an overdose of MAVENCLAD.