Mavenclad Contraindications

MAVENCLAD is contraindicated in patients with hypersensitivity to cladribine or to any of the tablet excipients listed in Description.
MAVENCLAD therapy must not be initiated in patients who are infected with the human immunodeficiency virus (HIV).
MAVENCLAD must not be initiated in patients with active chronic infections (tuberculosis, hepatitis) (refer to Precautions).
MAVENCLAD therapy must not be initiated in immunocompromised patients, including patients receiving immunosuppressive or myelosuppressive therapy with agents such as cyclosporin, methotrexate, mitoxantrone, azathioprine, natalizumab, or chronic use of corticosteroids.
Acute short-term therapy with corticosteroids can be administered.
MAVENCLAD must not be used in patients with moderate or severe renal impairment (creatinine clearance < 60 mL/min).
MAVENCLAD is contraindicated during pregnancy and breastfeeding (refer to Precautions and Use in Pregnancy & Lactation).
MAVENCLAD is contraindicated in active malignancy.