IV Adult ≥18 yr RA 3 mg/kg infusion over a 2-hr period followed by additional 3 mg/kg infusion doses at 2 & 6 wk after the 1st infusion then every 8 wk thereafter. To be given concomitantly w/ MTX.
Moderately to severely active Crohn's disease 5 mg/kg infusion over a 2-hr period. Maintenance: Additional 5 mg/kg infusions at 2 & 6 wk after the initial dose followed by infusions every 8 wk.
Fistulizing Crohn's disease Initially 5 mg/kg infusion over a 2-hr period followed w/ additional 5 mg/kg infusion doses at 2 & 6 wk after the 1st infusion. Responding patient: Additional 5 mg/kg infusions every 8 wk or re-administration if signs & symptoms of the disease recur followed by 5 mg/kg infusions every 8 wk.
UC, psoriatic arthritis & psoriasis 5 mg/kg infusion over a 2-hr period followed by additional 5 mg/kg infusion doses at 2 & 6 wk after the 1st infusion then every 8 wk thereafter.
Ankylosing spondylitis 5 mg/kg infusion over a 2-hr period followed by additional 5 mg/kg infusion doses at 2 & 6 wk after the 1st infusion then every 6-8 wk.
Re-administration for Crohn's disease & RA Re-administer w/in 16 wk following the last infusion if signs & symptoms recur.
Ped 6-17 yr Crohn's disease & UC 5 mg/kg infusion over a 2-hr period followed by additional 5 mg/kg infusion doses at 2 & 6 wk after the 1st infusion then every 8 wk thereafter.