Hymovis Dosage/Direction for Use

HYMOVIS is intended to be injected into the knee joint and is administered as a two intra-articular injection regimen. Standard intra-articular injection site preparation and strict aseptic administration technique must be followed.
Using an 18 - 20 gauge needle, it is recommended to remove synovial fluid or effusion before injecting HYMOVIS. Do not use the same syringe for removing synovial fluid and for injecting HYMOVIS; however, the same 18 - 20 gauge needle can be used.
Remove the protective rubber cap on the tip of the syringe and securely attach a needle (18 - 20 gauge) to the tip. Twist the tip cap before pulling it off, as this will minimize product leakage.
To ensure a tight seal and prevent leakage during administration, secure the needle tightly while firmly holding the luer hub. Take care not to rotate the hub during needle attachment which can lead to loosening of the hub. Do not overtighten or apply excessive leverage when attaching the needle or removing the needle guard, as this may break the syringe tip.
Inject the full 3 mL in one knee only (do not overfill the joint). If treatment is bilateral, a separate syringe should be used for each knee.
Administer the second injection of HYMOVIS in a week after the first injection following the same guidelines.