Goofice Special Precautions

Abdominal pain or diarrhoea: GOOFICE may cause abdominal pain or diarrhoea; dose reduction, drug interruption, or discontinuation should be considered depending on the patient's symptoms, and the need for continuing treatment with GOOFICE should be carefully evaluated on a regular basis.
Serious liver disorder: GOOFICE may fail to achieve its expected efficacy in patients with biliary obstruction or reduced bile acid secretion, etc., because these patients may not secrete the amount of bile acid enough to show therapeutic effect on constipation. GOOFICE should be administered with care in these patients (see Pharmacology: Pharmacodynamics under Actions).
Precaution concerning use: Precaution concerning the dispensing of the drug: Patients who are given drugs supplied in PTP package must be instructed to remove the drugs from the PTP sheet before taking drugs. [It has been reported that, if the PTP sheet is swallowed, the sharp corners of the sheet may puncture the esophageal mucosa causing perforation and resulting in serious complications, such as mediastinitis.]
Discontinuation of treatment: There is no data showing that discontinuation of GOOFICE does not lead to rebound effects (see Dosage & Administration).
Effects on ability to drive and use machines: There is no evidence of drug effects on the ability to drive or operate machinery.
Use in Children: Safety has not been established in low-birth-weight infants, neonates, nursing infants, infants, or pediatric patients (no clinical experience) (see Dosage & Administration).