Dompel Drug Interactions

The concomitant administration of domperidone with phenothiazines, butyrophenones and rauwolfia alkaloids may induce the endocrine disturbances or extrapyramidal disorders. If necessary, monitored carefully and administered cautiously.
Should be administered cautiously in patients receiving digitalis preparations.
The concomitant administration of domperidone with anticholinergic agents may compromise the beneficial effects of domperidone because of depressing the promoting action of gastrointestinal motility.
Theologically, domperidone may have an effect on the absorption of oral preparations, especially slow-releasing or enteric-coated preparations because of increasing gastric motility. But in patients stabilized with digoxin or acetaminophen, the concomitant administration of domperidone had no effect on plasma concentration of these drugs.
It is not reported that domperidone enhances the effect of neuroleptics.
Domperidone inhibits peripheral adverse reactions eg, dyspepsia, nausea, vomiting, induced by dopamine agonist (eg, bromocriptine, levodopa), but has no effect on central nervous system.
As the concomitant administration of domperidone with antacids or acid secretion inhibitors lowers biologic activity of domperidone, these drugs should not be used together.
The actions of domperidone on gastrointestinal function may be antagonised by antimuscarinics and opioid analgesics.