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Filgrastim or recombinant human granulocyte-colony stimulating factor (G-CSF), by means of genetic engineering technology, has similar bioactivity in vivo as well as in vitro as compared with natural human G-CSF.
G-CSF is one of the main factors modulating granulocytopoiesis and selectively acts on megakaryocytic progenitors to stimulate its multiplication and differentiation as well as to enhance functions and quantity of neutral granulocytes.
Filgrastim stimulates the production of neutrophil and may reduce the duration of chemotherapy-induced neutropenia and thereby reduce the incidence of associated sepsis.
