Cytotoxic-induced neutropenia Adult & childn 500,000 u/kg SC/IV infusion over 30 min daily started not <24 hr after cytotoxic chemotherapy, continue until neutrophil count is normal usually up to 14 days.
Myeloablative therapy followed by bone marrow transplantation 1 million u/kg IV infusion over 30 min or SC/IV infusion over 24 hr daily started not <24 hr after cytotoxic chemotherapy (& w/in 24 hr of bone marrow infusion), adjust according to neutrophil count.
Mobilization of peripheral blood progenitor cells for autologous infusion Monotherapy: 1 million u/kg SC inj/infusion (24 hr) daily for 5-7 days. Adjunct to myelosuppresive chemotherapy: 500,000 u/kg SC inj daily until neutrophil count is normal.
SC Mobilization of peripheral blood progenitor cells in normal donors for allogeneic infusion Adult <60 yr & adolescent >16 yr 1 million u/kg daily for 4-5 days.
Severe chronic neutropenia Adult & childn Initially 1.2 million u/kg daily in sinlge or divided doses.
Persistent neutropenia in HIV infection Initially 100,000 u/kg daily increased until neutrophil count is normal. Max: 400,000 u/kg daily.
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