Gastrointestinal disturbances (including nausea, vomiting and diarrhea), anorexia, headache, asthenia, fever, musculoskeletal pain, bone pain, rash, alopecia, injection site reactions and leukocytosis. Less frequent adverse effects include chest pain, hypersensitivity reactions (including anaphylaxis and bronchospasm) and arthralgia. There have been reports of pulmonary infiltrates leading to acute respiratory distress syndrome.