Each Film-Coated tablet contains: Cefuroxime (as axetil) 500 mg.
Viacef (Cefuroxime axetil) film-coated tablet contains cefuroxime as cefuroxime axetil, is a semi synthetic, broad-spectrum cephalosporin antibiotic for oral administration.
Pharmacology: Pharmacodynamics: Cefuroxime is a β-lactam type antibiotic. More specifically, it is a second generation cephalosporin that work the same way as penicillins, they interfere with the peptidoglycan synthesis of the bacterial wall by inhibiting the final transpeptidation needed for the cross-links. This effect is bactericidal.
Cefuroxime is effective against the following organisms: Aerobic Gram-positive Microorganisms: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes. Aerobic Gram-negative Microorganisms: Escherichia coli, Haemophilus influenzae (including beta-lactamase-producing strains), Neisseria gonorrhoeae (including beta-lactamase-producing strains), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (including beta-lactamase producing strains), Spirochetes, Borella burgdorferi. Cefuroxime axetil is the prodrug.
Pharmacokinetics: Absorption and Fate: Cefuroxime axetil is absorbed from the gastro-intestinal tract and it is rapidly hydrolyzed in the intestinal mucosa and blood to cefuroxime. The absorption of cefuroxime axetil is enhanced in the presence of food. Peak plasma concentrations are reported about 2 to 3 hours after an oral dose. Cefuroxime is widely distributed in the body including pleural fluid, sputum, bone, synovial fluid, and aqueous humour, but only achieves therapeutic concentrations in the CSF when the meninges are inflamed. It crosses the placenta and has been detected in breastmilk.
Cefuroxime is excreted unchanged, by glomerular filtration and renal tubular secretion, and high concentrations are achieved in the urine.
In the treatment of infections such as lower respiratory tract infections, upper respiratory tract infections, genito-urinary tract infections, skin and soft tissue infections, caused by sensitive bacteria.
The usual course of therapy is 7 days (Range 5 - 10 days). Cefuroxime axetil should be taken after food for optimum absorption.
For uncomplicated urinary tract infections: 125 mg twice daily.
Respiratory tract infections: 250-500 mg daily.
Uncomplicated gonorrhea: Single dose 4 g or as prescribed by the doctor.
As with other broad-spectrum antibiotics, prolonged administration of cefuroxime axetil may result in overgrowth of non susceptible microorganisms. If superinfection occurs during therapy, appropriate measures should be taken.
Cephalosporins, including cefuroxime axetil, should be given with caution to patients receiving concurrent treatment with potent diuretics because these diuretics are suspected to adversely affecting renal function.
Cefuroxime axetil, as with other broad-spectrum antibiotics, should be prescribed with caution in individuals with a history of colitis. The safety and effectiveness of cefuroxime axetil have not been established in patients with gastrointestinal malabsorption. Patients with gastrointestinal malabsorption were excluded from participating in clinical trials of cefuroxime axetil.
Gastro-intestinal disturbances, including diarrhea, nausea, and vomiting, have occurred in some patients receiving cefuroxime axetil. There have been rare reports of erythema multiforme, including the Steven-Johnson syndrome, and toxic epidermal necrolysis.
Store at temperatures not exceeding 30°C.
J01DC02 - cefuroxime ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.
Viacef tab 500 mg
100's (P5,194/box);30's
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