Viacef Mechanism of Action

Pharmacology: Pharmacodynamics: Cefuroxime is a β-lactam type antibiotic. More specifically, it is a second generation cephalosporin that work the same way as penicillins, they interfere with the peptidoglycan synthesis of the bacterial wall by inhibiting the final transpeptidation needed for the cross-links. This effect is bactericidal.
Cefuroxime is effective against the following organisms: Aerobic Gram-positive Microorganisms: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes. Aerobic Gram-negative Microorganisms: Escherichia coli, Haemophilus influenzae (including beta-lactamase-producing strains), Neisseria gonorrhoeae (including beta-lactamase-producing strains), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (including beta-lactamase producing strains), Spirochetes, Borella burgdorferi. Cefuroxime axetil is the prodrug.
Pharmacokinetics: Absorption and Fate: Cefuroxime axetil is absorbed from the gastro-intestinal tract and it is rapidly hydrolyzed in the intestinal mucosa and blood to cefuroxime. The absorption of cefuroxime axetil is enhanced in the presence of food. Peak plasma concentrations are reported about 2 to 3 hours after an oral dose. Cefuroxime is widely distributed in the body including pleural fluid, sputum, bone, synovial fluid, and aqueous humour, but only achieves therapeutic concentrations in the CSF when the meninges are inflamed. It crosses the placenta and has been detected in breastmilk.
Cefuroxime is excreted unchanged, by glomerular filtration and renal tubular secretion, and high concentrations are achieved in the urine.