Toridon Special Precautions

Domperidone may be associated with an increased risk of heart rhythm disorder and cardiac arrest. The risk may be more likely in those over 60 years old or in those taking doses higher than 30 mg per day. Therefore, domperidone should be used with caution in older patients. Patients older than 60 years of age should consult the physician before taking domperidone.
Due to increased risk of ventricular arrhythmia, domperidone is not recommended in patients with known existing prolongation of cardiac conduction intervals, particularly QTc. In patients with significant electrolyte disturbances or bradycardia or in patients with underlying cardiac diseases such as cardiac heart failure.
Domperidone is metabolized via cytochrome P450 isoenzyme CYP3A4. That concomitant use of drugs that is significantly inhibit the enzyme may result in increased plasma levels of domperidone. Co-administration of domperidone with potent CYP3A4 inhibitors which have been shown to cause QT interval prolongation should be avoided.
Domperidone is not recommended for chronic use or for the routine prophylaxis of postoperative nausea and vomiting.
Use in Pregnancy & Lactation: Domperidone should only be used during pregnancy when justified by the anticipated therapeutic benefit. The amount of domperidone that could be ingested by an infant through breast milk is low. It is not known whether this is harmful to the newborn. Therefore, breast-feeding is not recommended for women who are taking domperidone.