Domperidone is contraindicated in patients with known hypersensitivity to domperidone or any of the excipients.
Prolactin releasing pituitary tumor (prolactinoma).
Patients with moderate or severe hepatic impairment.
Gastrointestinal hemorrhage, obstruction, perforation or conditions where gastric motility could be harmful.
Co-administration with potent CYP3A4 inhibitors which have been shown to cause QT interval prolongation.