The absorption of Nadifloxacin after the application of Nadifloxacin to the human skin is very low and therefore, the interaction with other drugs concomitantly administered by systemic route is very unlikely. There is no evidence that shows that the effectiveness of systemically administered drugs could be influenced by the topical use of Nadifloxacin. Nadifloxacin can produce skin irritation and thus it is possible that its use together with peeling agents, astringents and products containing irritant substances as aromatic agents and alcohols, can result in an increase in skin irritation.
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