Nadifloxacin cream should be applied on a clean and dry affected areas twice a day, once in the morning and again before retiring to bed. Extra care should be exercised when applying Nadifloxacin cream near the eyes and lips. To avoid infections, Nadifloxacin Cream should be applied using a swab. Nadifloxacin should not be used under occlusive conditions. The duration of the treatment is, in general, up to 8 weeks but can be extended up to a maximum of 12 weeks if this is considered as acceptable from a medical point of view.