Patients with hypersensitivity to carvedilol or any component of Duobloc. Unstable or decompensated heart failure. Clinically manifest liver dysfunction. As with other α-blockers, Duobloc must not be used in patients with: 2nd- and 3rd-degree atrioventricular (AV) block (unless a permanent pacemaker is in place), severe bradycardia (<50 bpm), sick sinus syndrome (including sinoatrial block), severe hypotension (systolic blood pressure <85 mmHg), cardiogenic shock, history of bronchospasm or asthma, history of other obstructive lung disorder.
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