Cefuvex Drug Interactions

750 mg: Probenecid reduces the renal clearance of cefuroxime.
1.5 g: Nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporins.
A false-positive reaction for glucose in the urine may occur with copper reduction tests (Benedict's or Fehling's solution or with CLINITEST tablets) but not with enzyme-based tests for glycosuria. As a false-negative result may occur in the ferricyanide test, it is recommended that either the glucose oxidase or hexokinase method be used to determine blood plasma glucose levels in patients receiving this drug. Cefuroxime does not interfere with the assay of serum and urine creatinine by the alkaline picrate method.
Cefuroxime is incompatible with the following drugs: amikacin sulfate, gentamicin, kanamycin, tobramycin, neomycin, aureomycin hydrochloride, tetracycline hydrochloride, colistin sodium methanesulfonate, polymyxin B sulfate, erythromycin gluconate, erythromycin lactobionate, lincomycin, soluble barbiturates, calcium chloride, calcium glucoheptonate, diphenhydramine hydrochloride as well as other antihistamines, lidocaine, norepinephrine, metaraminol, ritalin, succinylcholine, etc. And it may also be incompatible with the following drugs occasionally: penicillin, methicillin, hydrocortisone sodium succinate, phenytoin sodium, prochlorperazine, vitamin B group, vitamin C and protein hydrolysate.
Concurrent treatment of this drug with potent diuretics (e.g. furosemide, ethacrynic acid and bumetanide), antineoplastics (e.g. carmustine and streptozotocin), or aminoglycoside antibiotics may increase the risk of nephrotoxicity.
Clavulanic acid may increase the antibacterial activity of cefuroxime against some cefuroxime-resistant beta-lactamase producing Gram-negative bacilli.