ACC Drug Interactions

Combined administration of acetylcysteine with antitussives may cause a dangerous secretory congestion due to the reduced cough reflex, so that an especially careful diagnosis is required for this combination treatment.
Reports to date on an inactivation of antibiotics due to acetylcysteine exclusively refer to in vitro experiments in which the relevant substances were mixed directly. Nevertheless for safety reasons, oral antibiotics should be administered separately and at an interval of at least 2 hours. This does not apply to cefixime and loracarbef.
Acetylcysteine/glyceryl trinitrate: The concomitant administration of acetylcysteine can potentially result in an intensification of the vasodilatory and inhibition of platelet aggregation effects of glyceryl nitrate (nitroglycerine).
If concomitant treatment with glyceryl trinitrate and acetylcysteine is considered necessary, patients should be monitored for the possible development of hypotension, which can be serious, and advised of the possibility of headaches.
Activated carbon in high doses (as an antidote) can reduce the effectiveness of acetylcysteine.
Changes in the determination of laboratory parameters: Acetylcysteine can affect the colorimetric determination of salicylates.
In urine tests, acetylcysteine can affect the results of determinations of ketone bodies.
The dissolution of acetylcysteine formulations together with other medicinal products is not recommended.