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Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with β-lactams. These reactions are more apt to occur in persons with a history of sensitivity to multiple allergens.
Serious anaphylactic reactions require immediate emergency treatment with epinephrine, oxygen, steroids IV and airway management, including intubation, may also be administered as indicated.
Clostridium difficile-associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including Zimilast and may range in severity from mild diarrhea to fatal colitis.
