Fully susceptible organisms including gram +ve & gram -ve aerobes & anaerobes Mild: 250 mg 6 hrly. Total daily dose: 1 g. Moderate: 500 mg 8 hrly; 500 mg 6 hrly. Total daily dose: 1.5 g; 2 g. Severe life-threatening only: 500 mg 6 hrly. Total daily dose: 2 g.
Uncomplicated UTI 250 mg 6 hrly. Total daily dose: 1 g.
Complicated UTI 500 mg 6 hrly. Total daily dose: 2 g.
Moderately susceptible organisms, primarily some strains of P. aeruginosa Mild: 500 mg 6 hrly. Total daily dose: 2 g. Moderate: 500 mg 6 hrly; 1 g 8 hrly. Total daily dose: 2 g; 3 g. Severe life-threatening only: 1 g 8 hrly; 1 g 6 hrly. Total daily dose: 3 g; 4 g.
Uncomplicated UTI 250 mg 6 hrly. Total daily dose: 1 g.
Complicated UTI 500 mg 6 hrly. Total daily dose: 2 g. Max total daily dosage: not exceed 59 mg/kg/day or 4 g daily.
Childn 3 mth Non-CNS infections 15-25 mg/kg/dose 6 hrly,
4 wk-3 mth 25 mg/kg 6 hrly,
1-4 wk 25 mg/kg 8 hrly,
<1 wk 25 mg/kg 12 hrly. Doses ≤500 mg should be given by IV infusion over 15-30 min. Doses >500 mg should be given by IV infusion over 40-60 min.
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