Zimilast Special Precautions

General: Central Nervous System (CNS) adverse experiences eg, confusional states, myoclonic activity and seizures have been reported during treatment with Zimilast especially when recommended dosages were exceeded.
Patients with creatinine clearances of 5 mL/min/1.73 m² should not receive Zimilast unless hemodialysis is instituted within 48 hrs.
For patients on hemodialysis, Zimilast is recommended only when the benefit outweighs the potential risk of seizures.
Skipping doses or not completing the full course of therapy may decrease the effectiveness of the immediate treatment, and increase the likelihood that bacteria will develop resistance and will not be treatable by Zimilast or other antibacterial drugs in the future. Diarrhea is common problem caused by antibiotics.
Zimilast is not for direct infusion.
Use in pregnancy & lactation: Pregnancy Category: C.
Zimilast should be used during pregnancy only if the potential benefit justifies the potential risk to the mother and fetus.
Caution should be exercised when Zimilast is administered to nursing women.