Gastrointestinal disorders eg, diarrhea, loose stools, abdominal pain, constipation, anorexia, nausea, vomiting, abdominal pain and loss of appetite may occur with the combination of voglibose. These adverse reactions occur most frequently during initiation of therapy and resolve spontaneously in most cases. To prevent them, it is recommended that metformin hydrochloride be taken in 2 or 3 daily doses during or after meals. A slow increase of the dose may also improve gastrointestinal tolerability.
Skin and Subcutaneous Tissue Disorders: Very rarely skin reactions eg, erythema, pruritus, and urticaria have been seen. In such a case, voglibose tablets should be discontinued. Increased AST or ALT may also occur. When voglibose is used in combination with other antidiabetic drugs, hypoglycemia may occur (0.1% to <5%).