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Pharmacological Classification: Antihistamine, antiemetics and antivertigo preparations.
Pharmacology: Cinnarizine inhibits contractions of vascular smooth muscle cells by blocking calcium channels.
Cinnarizine increases erythrocyte deformability and decreases blood viscosity in vitro.
Cinnarizine inhibits stimulation of the vestibular system.
The peak plasma levels of cinnarizine are obtained 1-3 hrs after intake. Cinnarizine disappears from plasma with a t½ of 4 hrs.
Cinnarizine is completely metabolised. About 1/3 of these metabolites are eliminated in the urine and 2/3 in the faeces.
The plasma protein-binding of cinnarizine is 91%.
