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Adults: The patient should be placed on standard cholesterol lowering diet before receiving Atorvastatin and should continue on this diet during treatment with Atorvastatin, Hypercholesterolaemia (Heterozygous Familial and Nonfamilial) and Mixed Dyslipidemia. The therapy should be initiated at a dose of 10 mg daily. The dose range is 10-80 mg once daily. Atorvastatin can be administered as a single dose at any time of the day with or without food. Individualisation of the therapy should be done according to goal of therapy and response. Lipid levels should be analysed within 2-4 weeks of initiation of therapy and/or dose escalation and the dosage adjusted accordingly. The LDL-C levels should be used to initiate and assess the treatment response. If LDL-C values are unavailable then total-C values can be used to monitor therapy.
Homozygous Familial Hypercholesterolaemia: Atorvastatin should be used as an adjunct to other lowering treatments (e.g. LDL apheresis) in these patients or if such treatments are unavailable. The recommended dose is 10 to 80 mg daily.
Patients with renal insufficiency: No dosage adjustments are required.
Patients with hepatic insufficiency: Exposure to the drug is greatly increased in moderate to severe hepatic dysfunction. Due caution should be exercised in patients who consume substantial quantities of alcohol and/or have a history of liver disease.
