Tonact

Tonact Drug Interactions

atorvastatin

Manufacturer:

Lupin

Distributor:

Maxxcare
Full Prescribing Info
Drug Interactions
Concurrent administration of cyclosporin, fibric acid derivatives, erythromycin, azole antifungals or niacin with HMG-CoA reductase increases the risk of myopathy. HMG-CoA reductase inhibitors are metabolised by cytochrome P450 3A4, while combining atorvastatin with other drugs which are substrate of this isoenzyme the possibility of change in plasma drug levels of either drug should be considered.
Digoxin: Co-administration of multiple doses of atorvastatin with digoxin increases the steady state plasma digoxin concentration by approximately 20% careful monitoring is required in patients taking digoxin.
Erythromycin: It is a known inhibitor of cytochrome P450 3A4; concurrent administration with atorvastatin leads to higher plasma concentrations of atorvastatin.
Oral contraceptives: Concurrent administration of atorvastatin with oral contraceptives containing norethisterone and ethinyl oestradiol leads to increased plasma concentration of noresthisterone and ethinyl oestradiol.
Warfarin: Minimal decrease in prothrombin time may occur when warfarin and atorvastatin are administered concurrently, patients receiving warfarin should be closely monitored when atorvastatin is added to their therapy.
Antacid: Co-administration with antacid causes no alteration in LDL-C reduction even though plasma concentrations of atorvastatin are reduced approximately by 35%.
Colestipol: Although plasma concentrations are lower when colestipol is administered with atorvastatin, the lipid lowering effects are greater than when either drug is given alone.
Cimetidine: No interaction has been observed of atorvastatin with cimetidine.
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