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Tonact

Tonact

atorvastatin

Manufacturer:

Lupin

Distributor:

Maxxcare
Concise Prescribing Info
Contents
Atorvastatin Ca
Indications/Uses
Adjunct to diet for reduction of elevated total-cholesterol, LDL-cholesterol, apolipoprotein B, & triglycerides in patients w/ primary hypercholesterolaemia (heterozygous familial & non familial) & mixed dyslipidemia. Adjunct to diet for the treatment of patients w/ elevated serum triglyceride levels. Adjunct to lipid lowering treatment in patients w/ homozygous familial hypercholesterolaemia.
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Dosage/Direction for Use
Adult Individualized dosage. Initially 10 mg daily. Dose range: 10-80 mg once daily. Homozygous familial hypercholesterolaemia 10-80 mg daily as adjunct to other lipid-lowering treatments.
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Overdosage
View Tonact overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Active liver disease or unexplained persistent serum transaminase elevations exceeding 3 times the upper limit of normal. Pregnancy & lactation.
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Special Precautions
Perform liver function tests prior to & at 12 wk following initiation of therapy & dose elevation. Reduce dose or discontinue therapy if increase in ALT levels >3 times the upper limit of normal persists. Alcoholics or patients w/ history of liver disease. Skeletal muscle effects; rhabdomyolysis w/ acute renal failure secondary to myoglobinuria has been reported w/ other drugs of this class. Discontinue therapy in cases of marked elevated CPK levels or diagnosed or suspected myopathy, or w/ a risk factor predisposing to development of renal failure secondary to rhabdomyolysis (eg, hypotension, major surgery, trauma, severe metabolic, endocrine & electrolyte disorders & uncontrolled seizures). Hepatic insufficiency.
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Adverse Reactions
Constipation, flatulence, dyspepsia, abdominal pain, headache, nausea, myalgia, asthenia, diarrhoea, insomnia, elevated serum ALT & CPK levels.
Drug Interactions
Increased risk of myopathy w/ cyclosporin, fibric acid derivatives, erythromycin, azole antifungals or niacin. Increased steady state plasma digoxin conc w/ multiple doses of atorvastatin. Higher plasma conc of atorvastatin w/ erythromycin. Increased plasma conc of norethisterone & ethinyl oestradiol. Decreased prothrombin time w/ warfarin. Lower plasma conc w/ colestipol.
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Storage
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Description
View Tonact description for details of the chemical structure and excipients (inactive components).
Action
View Tonact mechanism of action for pharmacodynamics and pharmacokinetics details.
MIMS Class
Dyslipidaemic Agents
ATC Classification
C10AA05 - atorvastatin ; Belongs to the class of HMG CoA reductase inhibitors. Used in the treatment of hyperlipidemia.
Presentation/Packing
Form
Tonact FC tab 10 mg
Packing/Price
10 × 10's
Form
Tonact FC tab 20 mg
Packing/Price
10 × 10's
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