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Use with caution in asthmatic patients, history of bronchospasm and peptic ulceration. Caution in epileptic patients and a patient at risk of convulsions is recommended.
Dosage adjustment is necessary in patients with moderate or severe renal impairment. There have been very few reports of severe skin lesions eg, Stevens-Johnson syndrome and toxic epidermal necrolysis (TEN) in temporal association with the administration of expectorants eg, ambroxol hydrochloride. Do not use before bedtime.
Use in pregnancy: Acetylcysteine is possibly safe when taken orally, delivered through a hole in the windpipe or breathed in. Acetylcysteine crosses the placenta, but there is no evidence so far linking it with harm to the unborn child or mother. However, N-acetyl cysteine should only be used in pregnant women when clearly needed eg, as in cases of acetaminophen toxicity.
