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Rabeprazole: Rabeprazole is metabolized in the liver by cytochrome P-450 (CYP450). Hence, co-administration with warfarin could lead to increase in prothrombin time although it is not significant. Even metabolism of cyclosporine is inhibited by rabeprazole when concomitantly advocated. Since Rablet-I inhibits gastric acid secretion, it could interfere with absorption of drugs wherein gastric pH is an important determinant of bioavailability eg, ketoconazole.
Itopride: No interactions with regard to serum binding have been detected for itopride with warfarin, diazepam, diclofenac, ticlopidine, nifedipine and vice-versa. Metabolic interactions are not to be expected because itopride is mainly metabolized by flavin monooxygenase and not by cytochrome P-450. Anticholinergic agents may reduce the action of itopride. Antiulcer agents eg, cimetidine, ranitidine did not affect the prokinetic action of itopride.
