Peptica-C Special Precautions

Aluminium may cause nausea, vomiting and constipation. Large doses can cause intestinal obstruction. Excessive or normal doses in patients with low phosphate diets may cause phosphate depletion accompanied by increased resorption and urinary excretion of calcium with the risk of osteomalacia. Osteomalacia, with chronic renal failure on high Aluminium dose as a phosphate binding agent.
Hypermagnesaemia may occur if renal function is impaired. Magnesium Hydroxide and other magnesium salts, in the presence of renal insufficiency, may cause central nervous system depression.
Aluminium and Magnesium may alter the absorption of other medicines from the gastro-intestinal tract if administered concomitantly.
Antacid use may mask the symptoms of internal bleeding secondary to nonsteroidal antiinflammatory drugs (Sing, 1996).
Antacids decrease the absorption of some drugs (eg, tetracyclines, quinolones, propranolol, atenolol, captopril, ranitidine, famotidine, and aspirin); avoid concomitant use of these drugs (Katz & Hallander, 1992).
Magnesium containing antacids may cause diarrhea and potentially lead to dehydration. Combining calcium or aluminum containing antacids with magnesium may reduce the incidence of diarrhea (Katz & Hallander, 1992).
Effects on Ability to Drive and Use Machines: None.