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Pharmacology: Pharmacodynamics: Peptica C contains Magnesium trisilicate, Dried Aluminium Hydroxide and Simethicone. Antacids provide rapid control of acidity by neutralizing the gastric acid. This action results in increase pH of stomach contents thus providing relief of the symptoms of hyperacidity. Acid concentration within the lumen of oesophagus is also reduced, resulting in an increase in intraesophageal pH.
Magnesium Trisilicate is a relatively weak, nonsystemic antacid and is an effective gastrointestinal adsorbent. The antacid action is exerted slowly, but is prolonged. Magnesium Trisilicate reacts with gastric contents to form a gelatinous Silicon Dioxide (which is said to protect ulcerated mucosal surfaces and promotes healing) and Magnesium Chloride. (Goodman & Gilman 7th Edition).
Peptic activity is inhibited through both Magnesium Trisilicate and Aluminium hydroxide by causing elevation of the gastric pH. Aluminium Hydroxide has a direct antipeptic action as well as a demulcent effect which helps protect the gastrointestinal mucosa and in this way prevents further irritation or erosion and so permits healing.
Simethicone aids in the dispersion and inhibits formation of "mucus-surrounded" gas bubbles in the gastrointestinal tract. This anti-foam action is exerted by changing the surface tension of the gas bubbles so that they coalesce. This permits escape of trapped gas, which then can be eliminated through belching or though passing flatus via the rectum. Simethicone has been widely investigated and used. It has a rapid action and is non-toxic. Being physiologically inert, it has no effect on digestion and is not absorbed through the gastrointestinal mucosa. Infants have been shown to tolerate Simethicone well.
By dispersing gas bubbles with the anti-flatulent, contact with the gastric antacid is facilitated. Coverage of the mucosa by the antacid and demulcent agents is also improved.
Pharmacokinetics: Orally administered Aluminium Hydroxide reacts slowly with the HCL acid in the stomach to form soluble Aluminium Chloride.
The presence of food decreases gastric emptying and prolongs the availability of Aluminium Hydroxide and increase the amount of Aluminium Chloride formed. Any absorbed aluminium is eliminated in the urine.
Aluminium compounds remaining in the gastrointestinal tract form insoluble, poorly Absorbed, Aluminium salts in the intestines including hydroxides, carbonates, phosphates and fatty acid derivatives, which are excreted in the faeces.
Magnesium trisilicate when given orally react with the gastric acid to form soluble magnesium chloride in the stomach. About 10% of Magnesium is slowly absorbed from the gastrointestinal tract and eliminated in the urine, the rest is excreted in the faeces. Simethicone is not absorbed from the gastrointestinal tract.
Toxicology: Preclinical Safety Data: Preclinical Data reveal no special hazard for humans based on conventional studies of pharmacology, repeated dose toxicity, genotoxicity and carcinogenic potential.
