Sign Out
There have been few cases of pemetrexed overdose. Reported toxicities included neutropenia, anemia, thrombocytopenia, mucositis and rash. Anticipated complications of overdose include bone marrow suppression as manifested by neutropenia, thrombocytopenia and anemia. In addition, infection with or without fever, diarrhea and mucositis may be seen. If an overdose occurs, general supportive measures should be instituted as deemed necessary by the treating physician.
In clinical trials, leucovorin was permitted for CTC grade 4 leukopenia lasting ≥3 days and immediately for CTC grade 4 thrombocytopenia, bleeding associated with grade 3 thrombocytopenia or grade 3 or 4 mucositis. The following IV doses and schedules of leucovorin were recommended for IV use: 100 mg/m2, IV once, followed by leucovorin 50 mg/m2, IV every 6 hrs for 8 days.
The ability of pemetrexed to be dialyzed is unknown.
