Non-Small Cell Lung Cancer (NSCLC) - Combination with Cisplatin: See Table 4.
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The following adverse events were greater in the fully supplemented group compared to the never supplemented group: Hypertension (11%, 3%), chest pain (8%, 6%) and thrombosis/embolism (6%, 3%). For fully supplemented patients treated with pemetrexed plus cisplatin, the incidence of CTC grade 3/4 fatigue, leukopenia, neutropenia and thrombocytopenia were greater in patients ≥65 years as compared to patients <65. No relevant effect for pemetrexed safety due to gender or race was identified except an increased incidence of rash in men (24%) compared to women (16%).
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