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Pharmacotherapeutic group: Agents against amoebiasis and other protozoal diseases. Nitroimidazole derivatives. ATC code: P01AB03.
Pharmacology: Pharmacodynamics: Orgyl contains ornidazole which is a 5-nitroimidazole derivative, antiprotozoal drug. It is extremely active against protozoa and bacterial infections. The drug is effective against Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia (Giardia intestinalis), and also some anaerobic bacteria such as Bacteroides spp., and Clostridium spp., Fusobacterium spp., and anaerobic cocci.
Pharmacokinetics: Following oral administration Ornidazole is easily and rapidly absorbed. Bioavailability is 90%. Peak plasma concentrations are reached within three hours after administration. Plasma protein binding of Ornidazole is about 13%. It penetrates into the cerebrospinal fluid, other body fluids and tissues very effectively. Ornidazole is metabolised in the liver. The half-life is about 13 hours. 63% of the dose is excreted with urine, and 22% is excreted with feces.
