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Orgyl potentiates effect of coumarin-type anticoagulants. It prolongs the muscle-relaxant effect of vecuronium bromide. Concomitant administration with other 5-nitroimidazole derivatives may lead to peripheral neuropathy, depression, epileptiform seizures.
Ornidazole does not inhibit aldehyde dehydrogenase. Hence it does not interact with alcohol.
Concomitant intake with other microsomal enzyme inducers (barbiturate, benzodiazepines, rifampicins, etc.) decreases half-life of ornidazole in serum. Microsomal enzyme inducers (cimetidine, macrolides, etc.) increase half-life of ornidazole.
Orgyl is not recommended in combination with neurotoxic and hematoxic drugs.
