Olan Dosage/Direction for Use

Olan should be administered on a once-daily schedule without regard to meals, generally beginning with 5-10 mg initially with a target dose of 10 mg/day within several days. Further dosage adjustments, if indicated, should generally occur at intervals of not less than 1 week. Daily dosage may subsequently be adjusted on the basis of individual clinical status within the range of 5-20 mg daily. An increase to a dose greater than the routine therapeutic dose of 10 mg/day ie, to a dose of ≥15 mg/day, is recommended only after appropriate clinical re-assessment.
Elderly: A lower starting dose (5 mg/day) is not routinely required but should be considered for those ≥65 years when clinical factors warrant so.
Patients with Hepatic or Renal Impairment: A lower starting dose (5 mg) may be considered for such patients.
Female Compared with Male Patients: The starting dose and dose range need not be routinely altered for female patients relative to male patients.
Nonsmoking Patients Compared with Smoking Patients: The starting dose and dose range need not be routinely altered for nonsmoking patients relative to smoking patients.
When >1 factor is present which might result in slower metabolism (female gender, geriatric age, nonsmoking status), consideration should be given to decreasing the starting dose. Dose escalation, when indicated, should be conservative in such patients.