Olan

Olan Drug Interactions

olanzapine

Manufacturer:

Micro Labs

Distributor:

Zizawa Healthcare
Full Prescribing Info
Drug Interactions
Potential for Other Drugs to Affect Olan: Single dose of antacid (aluminum, magnesium) or cimetidine does not affect the oral bioavailability of Olanzapine. The concomitant administration of activated charcoal reduces the oral bioavailability of Olan by 50-60%. The metabolism of Olan may be induced by concomitant smoking (the clearance of Olan is 33% lower and the terminal elimination half-life is 21% longer in nonsmokers compared to smokers) or carbamazepine therapy (clearance is increased by 44% and the terminal elimination half-life is reduced by 20% when administered with carbamazepine). Smoking and carbamazepine therapy induce P-450-1A2 activity.
The pharmacokinetics of theophylline, which is metabolized by P-450-1A2, is not altered by Olan. The effect of potent inhibitors of P-450-1A2 activity on Olan pharmacokinetics has not been studied.
Potential for Olan to Affect Other Drugs: Olan does not cause inhibition of the metabolism of imipramine/desipramine (P-450-2D6 or P-450-3A1/A2), warfarin (P-450-2C9), theophylline (P-450-1A2) or diazepam (P-450-3A4 and P-450-2C19). Olan shows no interaction when co-administered with lithium or biperiden.
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