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Symptoms: Toxic signs after administration of a single high dose of Moxifloxacin in animals included CNS and gastrointestinal effects.
Treatment: In the event of acute overdosage, the stomach should be emptied. ECG monitoring is recommended due to the possible prolongation of the QT interval. Adequate hydration must be maintained. Concomitant administration of charcoal with a dose of 400 mg oral Moxifloxacin will reduce systemic availability of the drug by more than 80% or 20% respectively. The application of charcoal may be useful to prevent excessive increase of systemic exposure to Moxifloxacin in cases of oral overdose.
