Severe allergic reactions. Patient w/ or history of CHD, heart failure, low BP; disturbances of heart rate; breathing problems, asthma or COPD; poor blood circulation disease eg, Raynaud's disease or syndrome; diabetes; overactivity of the thyroid gland; any kind of eye surgery (including cataract surgery); eye problems eg, eye pain, irritation, inflammation or blurred vision; dry eyes; angina (particularly Prinzmetal’s angina); viral infection of the eye caused by HSV. May change effects of some medicines used during anaesth. May discolour soft contact lenses. Avoid contact w/ soft lenses. Remove contact lenses prior to application & wait at least 15 min before reinsertion. Do not drive or use tools or machines until vision becomes clear again. Not recommended for use in patient <18 yr.