Imodium should not be used in the case of acute dysentery, which is characterized by blood in stools and elevated temperatures.
Fluid and electrolyte depletion may occur in patients who have diarrhoea. The use of Imodium does not preclude the administration of appropriate fluid and electrolyte therapy.
In some patients with acute ulcerative colitis, and in pseudomembranous colitis associated with broad-spectrum antibiotics, agents which inhibit intestinal motility or delay intestinal transit time have been reported to induce toxic megacolon. Imodium therapy should be discontinued promptly if abdominal distention occurs or if other untoward symptoms develop in patients with acute ulcerative colitis.