In case of overdosage, the following side effects may be observed: Constipation and neurological symptoms (myosis, muscular hypertonia, somnolence and bradypnoea).
If intoxication is suspected, naloxone can be given as an antidote. Since the duration of action of Imodium is longer than that of naloxone, the patient should be placed under constant observation for at least 48 hrs in order to detect a possible depression of the CNS.