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Potentiation of the hypoglycaemic action of Diaglu may occur with the concomitant administration of sulfonamides, salicylates, phenylbutazone, β-adrenoreceptor-blocking agents, monoamine oxidase inhibitors (MAOIs), ketoconazole and miconazole.
Diminution of hypoglycaemic action of Diaglu may occur with the concomitant administration of thiazide diuretics, corticosteroids and oestrogens.
Adjustment of dosage of hypoglycaemic agents may be required in patients suffering from intercurrent infections, traumas, shock or after anaesthesia.
When major surgery is to be performed, insulin therapy should be substituted for oral hypoglycaemics.
