General: Celecoxib metabolism is predominantly mediated via cytochrome P-450 2C9 in the liver. Co-administration of celecoxib with drugs that are known to inhibit 2C9 should be done with caution.
ACE Inhibitors: Reports suggest that NSAIDs may diminish the antihypertensive effect of angiotensin-converting enzyme (ACE) inhibitors.
Furosemide: NSAIDs can reduce the natriuretic effect of furosemide and thiazides in some patients.
Aspirin: Concomitant administration of aspirin with celecoxib may result in an increased rate of gastrointestinal ulceration or other complications.
Fluconazole: Concomitant administration of fluconazole at 200 mg once daily resulted in a 2-fold increase in celecoxib plasma concentration.