Use in pregnancy: In late pregnancy, celecoxib should be avoided because it may cause premature closure of the ductus arteriosus.
Use in lactation: Celecoxib is excreted in the milk of lactating rats at concentrations similar to those in plasma. It is not known whether celecoxib is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from celecoxib, a decision should be made whether to discontinue nursing or to discontinue celecoxib, taking into account the importance of celecoxib to the mother.