Pharmacology: Afix (cefixime) is a broad-spectrum cephalosporin antibiotic of the 3rd-generation for oral administration. It is a bactericidal antibiotic and is stable to hydrolysis by many β-lactamases. Afix kills bacteria by interfering the synthesis of the bacterial cell wall.
Afix is highly active against Neisseria gonorrhoeae, Haemophilus influenzae, Moraxella catarrhalis including β-lactamase producers, most of the Enterobacteriaceae, β-haemolytic Streptococci (Group A and B) and Streptococcus pneumoniae. Afix is more active than other oral cephalosporins against Escherichia coli, Klebsiella spp, Proteus mirabilis and Serratia marcescens. Afix is also active against Streptococcus pyogenes.
40-50% of an oral dose is absorbed from the gastrointestinal tract (GIT), whether taken with meals or not. The plasma half-life is usually about 3-4 hrs and may be prolonged when there is renal impairment. About 65% is bound to plasma protein. Afix is mainly excreted unchanged in bile and urine.
Treatment of the following acute infection, when caused by susceptible organisms: Urinary Tract Infections: Cystitis, cystourethritis, pyelonephritis, gonococcal urethritis.
Upper Respiratory Tract Infections (URTI): Otitis media and other URTI where the causative organism is known or suspected to be resistant to other commonly used antibiotics.
Lower Respiratory Tract Infections: Bronchitis, etc.
Typhoid fever.
Capsule: Adults: 1 or 2 caps (200-400 mg) as a single dose or in 2 divided doses daily for 7-14 days, according to the severity of the infection.
Suspension: Children >6 months: 8 mg/kg bodyweight as a single dose or in 2 divided doses for 7-14 days according to the severity of the infection or as follows: >12 years: Adult dose, 11-12 years: 15 mL or 300 mg, 5-10 years: 10 mL or 200 mg, 1-4 years: 5 mL or 100 mg, 6 months to 1 year: 3.75 mL or 75 mg.
Children <6 months: Not recommended.
Known hypersensitivity to cephalosporin antibiotics.
Use in children: Not recommended for children <6 months.
Afix should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis. Dosage adjustment is only necessary in severe renal failure (creatinine clearance <20 mL/min).
Use in pregnancy & lactation: No data are available, so it is probably best to avoid using Afix during pregnancy and by the nursing mothers.
No data are available, so it is probably best to avoid using Afix during pregnancy and by the nursing mothers.
Afix is generally well tolerated. The majority of adverse reactions observed in clinical trials was mild and self-limiting in nature.
Gastrointestinal Disturbances: Diarrhoea (if severe diarrhoea occurs, Afix should be discontinued), changes in color of stool, nausea, abdominal pain, dyspepsia, vomiting, flatulence have been reported.
Central Nervous System Disturbances: Headache, dizziness, etc.
Others: Hypersensitivity reactions which usually subsided upon discontinuation of therapy; infrequent and reversible haematological changes; elevation of serum amylase, etc.
Store at normal temperature and protect from sunlight.
J01DD08 - cefixime ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
Cap 200 mg x 1 x 10's. Powd for oral susp 100 mg/5 mL x 50 mL.
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