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Pharmacology: Afix (cefixime) is a broad-spectrum cephalosporin antibiotic of the 3rd-generation for oral administration. It is a bactericidal antibiotic and is stable to hydrolysis by many β-lactamases. Afix kills bacteria by interfering the synthesis of the bacterial cell wall.
Afix is highly active against Neisseria gonorrhoeae, Haemophilus influenzae, Moraxella catarrhalis including β-lactamase producers, most of the Enterobacteriaceae, β-haemolytic Streptococci (Group A and B) and Streptococcus pneumoniae. Afix is more active than other oral cephalosporins against Escherichia coli, Klebsiella spp, Proteus mirabilis and Serratia marcescens. Afix is also active against Streptococcus pyogenes.
40-50% of an oral dose is absorbed from the gastrointestinal tract (GIT), whether taken with meals or not. The plasma half-life is usually about 3-4 hrs and may be prolonged when there is renal impairment. About 65% is bound to plasma protein. Afix is mainly excreted unchanged in bile and urine.
