Vibramycin Use In Pregnancy & Lactation

Use in Pregnancy: Doxycycline has not been studied in pregnant patients. It should not be used in pregnant women unless, in the judgment of the physician, the potential benefit outweighs the risk (see Use in Children under Precautions).
Results of animal studies indicate that tetracyclines cross the placenta, are found in fetal tissues and can have toxic effects on the developing fetus (often related to retardation of skeletal development). Evidence of embryotoxicity has also been noted in animals treated early in pregnancy.
Lactation: As with other tetracyclines, doxycycline forms a stable calcium complex in any bone-forming tissue. A decrease in the fibula growth rate has been observed in prematures given oral tetracycline in doses of 25 mg/kg every six hours. This reaction was shown to be reversible when the drug was discontinued (see Use in Children under Precautions).
Doxycycline should be avoided in nursing mothers, as tetracyclines including doxycycline are present in the milk of lactating women who are taking a drug of this class.