Adult 200 mg on 1st day, then 100 mg daily.
Severe infection 200 mg daily.
Childn >8 yr >45 kg Adult dose,
≤45 kg 4.4 mg/kg, followed by 2.2 mg/kg.
More severe infection Max: 4.4 mg/kg.
Tick- & louse-borne relapsing fever, louse-borne typhus 100 or 200 mg single oral dose or 100 mg every 12 hr for 7 days.
Early Lyme disease 100 mg bd for 14-60 days.
Uncomplicated urethral, endocervical or rectal infection Adult 100 mg bd for 7 days.
Nongonococcal urethritis 100 mg bd for 7 days.
Lymphogranuloma venereum 100 mg bd for min of 21 days.
Uncomplicated gonococcal infection of cervix, rectum or urethra, pharynx 100 mg bd for 7 days + co-treatment w/ cephalosporin or quinolone.
Primary & secondary syphilis 100 mg bd for 2 wk.
Latent & tertiary syphilis 100 mg bd for 2-4 wk.
Acute pelvic inflammatory disease In-patient: 100 mg every 12 hr + cephalosporin then continue 100 mg bd for 14 days. Outpatient: 100 mg bd for 14 days + cephalosporin & probenecid.
Acne vulgaris 50-100 mg daily for up to 12 wk.
Chloroquine-resistant falciparum malaria 200 mg daily for at least 7 days.
Prophylaxis of malaria Adult 100 mg daily,
childn >8 yr 2 mg/kg daily.
Prophylaxis of cholera Adult 300 mg single dose.
Prevention of scrub typhus 200 mg single dose.
Prevention of traveler's diarrhea 200 mg on 1st day of travel as single dose, followed by 100 mg daily.
Prevention of leptospirosis 200 mg wkly.
Treatment of leptospirosis 100 mg bd for 7 days.
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