Vibramycin Indications/Uses

Treatment: Doxycycline is indicated for treatment of the following infections: Rocky Mountain spotted fever, typhus fever and the typhus group; Q fever, rickettsial pox and tick fevers caused by Rickettsiae; Respiratory infections caused by Mycoplasma pneumoniae; Psittacosis caused by Chlamydia psittaci; Lymphogranuloma venereum, caused by Chlamydia trachomatis; Uncomplicated urethral, endocervical or rectal infections in adults caused by Chlamydia trachomatis; Trachoma caused by Chlamydia trachomatis although the infectious agent is not always eliminated, as judged by immunofluorescence; Inclusion conjunctivitis caused by Chlamydia trachomatis may be treated with oral doxycycline alone or with a combination of topical agents; Granuloma inguinale (donovanosis) caused by Calymmatobacterium granulomatis; Early (Stage 1) Lyme disease caused by Borrelia burgdorferi; Louse-borne relapsing fever caused by Borrelia recurrentis; Tick-borne relapsing fever caused by Borrelia duttonii; Non-gonococcal urethritis (NGU) caused by Ureaplasma urealyticum (T-Mycoplasma).
Doxycycline is also indicated for the treatment of infections caused by the following gram-negative microorganisms: Acinetobacter species; Bacteroides species; Fusobacterium species; Brucellosis caused by Brucella species (in conjunction with streptomycin); Plague caused by Yersinia pestis; Tularemia caused by Francisella tularensis; Bartonellosis caused by Bartonella bacilliformis; Campylobacter fetus.
Because many strains of the following groups of microorganisms have been shown to be resistant to tetracyclines, culture and susceptibility testing are recommended.
Doxycycline is indicated for treatment of infections caused by the following gram-negative microorganisms, when bacteriologic testing indicates appropriate susceptibility to the drug: Shigella species; Uncomplicated gonorrhea caused by Neisseria gonorrhoeae; Respiratory infections caused by Haemophilus influenzae; Respiratory and urinary infections caused by Klebsiella species; Escherichia coli; Enterobacter aerogenes; Moraxella catarrhalis.
Doxycycline is indicated for treatment of infections caused by the following gram-positive microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug: Streptococcus species: A certain percentage of strains of Streptococcus pyogenes and Streptococcus faecalis have been found to be resistant to tetracycline drugs. Tetracyclines should not be used for streptococcal infections unless the organism has been demonstrated to be sensitive.
For upper respiratory infections due to group A beta-hemolytic streptococci, penicillin is the usual drug of choice, including prophylaxis of rheumatic fever. This includes: Upper respiratory tract infections caused by Streptococcus pneumoniae; Respiratory, skin and soft-tissue infections caused by Staphylococcus aureus. Tetracyclines are not the drug of choice in the treatment of staphylococcal infections.
When penicillin is contraindicated, doxycycline is an alternative drug in the treatment of: Actinomycosis caused by Actinomyces species; Infections caused by Clostridium species; Syphilis caused by Treponema pallidum and yaws caused by Treponema pertenue; Listeriosis caused by Listeria monocytogenes; Vincent's infection (acute necrotizing ulcerative gingivitis) caused by Leptotrichia buccalis (formerly, Fusobacterium fusiform).
Adjunctive treatment: In acute intestinal amebiasis, doxycycline may be a useful adjunct to amebicides.
In severe acne caused by acne vulgaris, doxycycline may be useful adjunctive therapy.
Treatment and Prophylaxis: Doxycycline is indicated for the prophylaxis and treatment of the following infections: Malaria caused by Plasmodium falciparum (in areas with chloroquine-resistant P. falciparum).
Leptospirosis caused by genus Leptospira.
Cholera caused by Vibrio cholerae.
Prophylaxis: Doxycycline is indicated as prophylaxis in the following conditions: Scrub typhus caused by Rickettsia tsutsugamushi; Traveler's diarrhea caused by enterotoxigenic Escherichia coli.